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含有S-equol的发酵大豆粉缓解了被卵巢切除的老鼠的绝经后症状

Byung Hee Choi¹, Kwanyong Choi², Soo-Yeon Park²

¹Department of Nano Bio Engineering, Seoul National University of Science and Technology, 232, Gongneung-Ro, Nowon-Gu, Seoul, 01811 Republic of Korea.

Food science and biotechnology

|March 20, 2025

概括

补充S-equol (SE5-OH) 可能有助于更年期后妇女通过减少热和改善骨健康. 这种发酵的大豆胚芽产品显示出作为激素治疗的替代方案的希望.

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
营养科学营养科学

背景情况:

更年期症状如热和骨质疏松症显著影响妇女的生活质量.
激素替代疗法 (HRT) 有安全问题,推动寻找替代品.
S-equol是一种大吉素代谢物,是治疗更年期症状的潜在植物性雌激素.

研究的目的:

研究含S-equol补充剂 (SE5-OH) 对更年期症状和骨质疏松症的疗效.
评估SE5-OH在卵巢切除 (OVX) 鼠标模型中的作用.

主要方法:

卵巢切除 (OVX) 的老鼠 (6个月和8周) 接受了SE5-OH.
评估了对子宫体重,子宫内膜厚度,体重,雌激素受体 (ER) 水平,素基因相关 (CGRP) 和骨周转标记物的影响.

主要成果:

在8周大的OVX大鼠中,SE5-OH降低了体重,并降低了肝脏和下丘脑的ER上调.
脑下垂体CGRP水平被SE5-OH降低,可能缓解热.
SE5-OH稳定了RANKL/OPG骨形成标记物,增加了骨中的ER,并改善了血清骨转换生物标记物.

结论:

SE5-OH显示出缓解更年期症状的潜力,包括发热.
该补充剂可能对绝经后妇女的代谢变化和骨质疏松症预防有好处.
SE5-OH为管理更年期后的健康问题提供了一个有希望的,由大豆衍生的替代品.

关键词:

雌激素受体的受体是什么热闪的热闪是因为热闪.更年期绝经绝经骨质疏松症是一种骨质疏松症.这就是S-equolol.

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