最近的SARS-CoV-2感染后艾滋病毒感染者的宏观血管功能
Ana S Salazar1,2, Louis Vincent3, Bertrand Ebner3
1Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
概括
艾滋病毒 (PWH) 和轻度COVID-19患者没有增加心血管疾病 (CVD) 风险或血管功能障碍. 这表明,得到良好控制的HIV可能会减轻与SARS-CoV-2相关的心血管疾病并发症.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染者 (PWH) 面临更高的血管功能障碍和心血管疾病 (CVD) 风险.
- SARS-CoV-2 感染与急性心血管疾病并发症有关.
- 在COVID-19后的PWH中评估宏血管功能对于了解心血管疾病风险至关重要.
研究的目的:
- 评估宏血管功能作为轻度SARS-CoV-2感染后PWH中心血管疾病风险的早期指标.
- 为了比较具有和没有COVID-19病史的PWH之间的血管功能.
主要方法:
- 招募的PWH (20-60岁) 病毒载量无法检测,正在接受稳定的抗逆转录病毒治疗,有轻微的COVID-19病史.
- 排除了患有糖尿病,末期病或先前存在的心脏/呼吸系统疾病的参与者.
- 评估了宏血管功能 (流量介导扩张,动脉硬) 并将心血管疾病风险因素与疫情前PWH1:1匹配的群体进行比较.
主要成果:
- 17名患有COVID-19的PWH (PWH/COV+) 与17名没有COVID-19的PWH (PWH/COV-) 相匹配.
- 在年龄,性别,BMI,艾滋病毒持续时间和心血管疾病风险因素 (胆固醇,血压) 方面,这些组是可比的.
- 在SARS-CoV-2感染后30天的流量介导扩张或动脉硬性方面没有发现显著差异.
结论:
- 最近的SARS-CoV-2感染并没有导致PWH的宏血管功能障碍或心血管疾病风险增加.
- 患有良好控制的HIV,避免SARS-CoV-2感染导致心血管疾病并发症的PWH患者的心血管疾病风险可能不会升高.
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