超血是COPD的一个被低估的风险因素
Jukka Mäenpää1, Isobel Anderson2, Caroline A Owen3
1Chief Medical Office, Research & Development, Patient Safety Biopharma, AstraZeneca, Gothenburg, Sweden.
概括
高血是严重慢性阻塞性肺病 (COPD) 患者的重大风险,特别是那些功能下降或糖尿病患者. 对这些人来说,定期监测水平至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
背景情况:
- 超血是一般患者群体中已知的死亡风险因素.
- 过高胆血症和慢性阻塞性肺部疾病 (COPD) 之间的关联未被充分认识到.
- 超血症可能会在COPD恶化期间和之后导致心血管死亡.
研究的目的:
- 为了研究中度至非常严重的COPD患者中高卡血症的患病率和危险因素.
- 探索高胆固醇血量与慢性病 (CKD),糖尿病 (DM) 和慢性慢性肺炎 (COPD) 患者的氨酸-氨酸-阿尔多斯特系统 (RAAS) 抑制剂使用之间的关系.
主要方法:
- 从两项临床试验中对7968名中度至极度严重的COPD患者队列的回顾性分析.
- 评估高血症和伴随性疾病之间的关联,包括CKD,DM和RAAS抑制剂的使用.
主要成果:
- 6.4%的COPD患者患有高血症,在全球慢性阻塞性肺病倡议 (GOLD) 阶段3 (6.8%) 和4 (8.0%) 的患病率增加,而GOLD 2 (5.3%) 的患病率增加.
- 随着功能下降,高血症的风险显著增加 (中度至重度功能损害的OR=2.29),并与DM (OR=1.28) 和 ангиотензин转化酶抑制剂 (ACEi) 使用相关 (OR=1.25).
- 仅在正常功能 (OR=1.63) 的患者中,RAAS抑制剂的使用与高胆血症有显著的关联.
结论:
- 严重和非常严重的COPD患者 (GOLD 3和4) 面临高血的风险.
- 降低功能,DM和ACEi使用是COPD中高卡利米亚的重要危险因素.
- 建议对COPD患者进行定期血清度监测,特别是那些患有GOLD阶段3和4的患者.
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
166
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
166
01:22Chronic Obstructive Pulmonary Disease
1.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.1K
01:20COPD: Pathogenesis and Clinical Features
219
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
219
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.7K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.7K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K