在帕金森病中NMSS和MDS-NMS之间的转换
Michela Garon1,2, José-Manuel Rojo-Albuin3, K Ray Chaudhuri4,5
1Padua Neuroscience Center (PNC), University of Padua, Padua, Italy.
概括
研究人员开发了转换公式来比较帕金森病患者的非运动症状量表 (NMSS) 和国际帕金森和运动障碍学会非运动评分量表 (MDS-NMS) 的分数. 这些方程允许在研究中直接比较数据.
科学领域:
- 神经学 神经学
- 临床评估 临床评估
- 帕金森病研究 帕金森病研究
背景情况:
- 帕金森病 (PD) 通过非运动症状显著影响患者.
- 两个关键的尺度,非运动症状尺度 (NMSS) 和国际帕金森和运动障碍学会非运动评级尺度 (MDS-NMS),评估这些症状,但在结构和评分上有所不同.
- 这种差异阻碍了在使用不同尺度的研究中直接比较数据.
研究的目的:
- 开发可靠的转换公式,用于在NMSS和MDS-NMS之间转换分数.
- 为了使帕金森病研究中的非运动症状能够进行直接比较,并提高数据的可比性.
主要方法:
- 利用了402名帕金森病患者从MDS-NMS初级验证研究中获得的数据.
- 使用斯皮尔曼等级相关性和肯德尔的W对应系数,评估了两个尺度的域和总分数之间的关联.
- 构建加权线性回归模型来推导得分转换方程.
主要成果:
- 斯皮尔曼等级相关性表明,MDS-NMS和NMSS (0.390.88) 的相应领域之间存在中度至强度的关联.
- 开发了一个公式来将NMSS总得分转换为MDS-NMS总得分:MDS-NMS = 11.629 + 1.624 × NMSS (R2 = 0.748).
- 开发了一个公式来将MDS-NMS总得分转换为NMSS总得分:NMSS = 2.475 + 0.495 × MDS-NMS (R2 = 0.771).
结论:
- 由此得出的转换方程为NMSS和MDS-NMS之间的分数交换提供了可靠的方法.
- 促进了在评估帕金森病非运动症状的各种研究中增强数据的可比性.
- 支持在运动障碍研究领域进行更完整的分析和元分析.
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