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Updated: Jun 17, 2026

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通过操纵微泡脂质成分来提高超声波和微泡介导基因传递的效率

Kushal Joshi1,2,3, Amin Jafari Sojahrood2,4, Rajiv Sanwal1,5

  • 1Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1T8, Canada.

ACS applied bio materials
|March 20, 2025
PubMed
概括

研究人员发现,改变微泡中的聚乙烯糖醇 (PEG) 衍生物显著影响了基因传递效率. 优化PEGylation可以在非病毒基因治疗应用中将基因传递效率增加三倍.

关键词:
在PEG衍生品中,PEG衍生品基因传递 基因传递 基因传递脂质外组成的成分微型气泡是一种微型气泡.超声波超声波是指超声波的使用.

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...