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饮食,微生物组和益生菌在疫苗疗效方面建立了至关重要的联系
Soumam Dutta1,2, Niloy Chatterjee1,3, Nicholas L F Gallina4,5
1Laboratory of Food Science and Technology, Food and Nutrition Division, University of Calcutta, Kolkata, India.
Critical reviews in microbiology
|March 20, 2025
概括
饮食和益生菌可以通过调节肠道微生物群来显著影响疫苗的疗效. 通过饮食优化肠道健康可能会增强对疫苗的免疫反应,特别是在脆弱人群中.
科学领域:
- 免疫学和微生物学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 疫苗的有效性受到各种因素的影响,但肠道微生物组的作用仍未得到充分探索.
- 肠道功能障碍与疫苗反应受损有关,这凸显了针对性干预的必要性.
- 了解肠道微生物群的影响在后疫情时代至关重要.
研究的目的:
- 审查饮食干预和益生菌如何调节肠道微生物群.
- 探索肠道微生物组组成和疫苗疗效之间的联系.
- 通过微生物组操纵来确定增强疫苗反应的潜在策略.
主要方法:
- 关于饮食,肠道微生物组,益生菌和疫苗疗效的综合文献综述.
- 对研究植物性和动物性食品对肠道微生物群的影响的分析.
- 对益生菌补充剂及其对免疫反应的影响的研究评估.
主要成果:
- 食纤维和多醇促进有益的肠道微生物,提高疫苗的疗效.
- 某些动物性食品,如乳清蛋白和鱼油,支持肠道活化和免疫反应.
- 和红肉可能会对疫苗的有效性产生负面影响,而益生菌的作用则取决于菌株和剂量.
结论:
- 饮食干预可以积极调节肠道微生物组,以提高疫苗的疗效.
- 通过饮食和益生菌向肠道微生物组为精确的疫苗接种策略提供了一个有希望的途径.
- 需要进一步的研究,以充分阐明饮食,微生物组和疫苗反应之间的复杂相互作用.
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