对酒精使用障碍的综合药理和社会心理干预措施
Silvia Minozzi1, Giusy Rita Maria La Rosa2, Francesco Salis3,4
1Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
The Cochrane database of systematic reviews
|March 20, 2025
概括
结合药理和心理社会干预措施可能会减少成年人饮酒障碍 (AUD) 的重度饮酒. 虽然潜在地增加了戒断,但其他结果的证据有限,这表明联合治疗对AUD恢复是安全和有益的.
科学领域:
- 成 药物 药物 药物 药物
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 酒精使用障碍 (AUD) 是一种明显的心理健康状况,其特点是强迫性饮酒.
- 许多患有AUD的个体对独立的心理社会或药物治疗没有充分的反应.
- 结合干预措施可能会提高治疗疗效,但强有力的证据有限.
研究的目的:
- 评估联合药理和心理社会干预措施在成人AUD治疗中的有效性.
- 将联合干预与单独的药物或心理社会干预或通常的治疗 (TAU) 进行比较.
主要方法:
- 21项随机对照试验 (RCT) 的系统性审查和元分析,涉及4746名参与者.
- 搜索了多个数据库,直到2023年11月,没有语言限制.
- 使用Cochrane的RoB 1工具评估偏差风险和使用GRADE的证据确定性.
主要成果:
- 与单独的社会心理治疗相比,联合干预可能会减少重度饮酒 (中度确定性证据).
- 观察到持续戒断的潜在增加 (低确定性证据).
- 与单独的心理治疗相比,在戒断日,严重不良事件或治疗中断时发现几乎没有影响 (中等确定性证据).
结论:
- 将药理干预措施添加到心理治疗中似乎是安全的,对AUD恢复有益.
- 综合干预与单独药物治疗或TAU的证据不太清楚,因为研究有限,证据确定性低.
- 建议进行进一步的研究,以比较联合干预与药物治疗或TAU.
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