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Updated: Jun 26, 2026

Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia
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多尺度模拟和人类胆氨酸酸酶突变的分析:关于线粒体神经胃肠道脑病变的结构,动力和功能影响的见解

Khushboo Bhagat1, Amar Jeet Yadav1, Aditya K Padhi1

  • 1Laboratory for Computational Biology & Biomolecular Design, School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi 221005, Uttar Pradesh, India.

The journal of physical chemistry. B
|March 20, 2025
PubMed
概括

线粒体神经胃肠道脑病变 (MNGIE) 突变使人体胺酸酶 (HTP) 不稳定,损害了胺酸的结合,导致功能障碍. 计算方法揭示了这些遗传变化如何导致疾病.

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