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Updated: May 21, 2025

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对耳障碍库存和耳功能指数的最小临床重要差异的估计
Milena Engelke1, Laura Basso1, Berthold Langguth1
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
概括
这项研究使用Tinnitus Handicap Inventory (THI) 和Tinnitus Functional Index (TFI) 确定了耳的临床重要差异 (MCID). 根据基线严重程度和时间,MCID值会有所不同,强调对声管理的具体情境解释.
科学领域:
- 听力学 听力学是指听力学.
- 临床心理学 临床心理学
- 健康 结果 研究 研究 结果
背景情况:
- 最小临床重要差异 (MCID) 对于评估声治疗的疗效至关重要.
- 对于耳测量现有的MCID值,如耳障碍目录 (THI) 和耳功能指数 (TFI),可能缺乏特定上下文的验证.
- 为了可靠地解释耳治疗结果,需要标准化的MCID估计.
研究的目的:
- 在耳患者中估计耳障碍库存 (THI) 和耳功能指数 (TFI) 的MCID.
- 调查基线耳严重程度和治疗持续时间对MCID值的影响.
- 为了比较不同的基于的方法来确定声中的MCID.
主要方法:
- 一个多中心随机临床试验,涉及欧洲耳中心.
- 使用了基于的方法,包括效果大小,接收器操作特性和 ΔTHI/TFI.
- 临床全球印象量表-改善 (CGI-I) 作为,测量标准误差评估随机变化.
主要成果:
- 对于THI,MCID估计范围从7.8到12,在12周后的点估计为11 (N=364).
- 对于TFI,MCID估计在7.3到9.4之间,在12周后的点估计为9 (N=359).
- 较高的基线 tinnitus 严重程度和较长的时间间隔需要更大的得分减少临床意义.
结论:
- 耳MCID值是特定于背景的,受基线严重程度和时间间隔的影响.
- 为了提高 tinnitus 结果测量的可比性,需要就最佳的基于 anchor 的方法达成共识.
- 这些发现有助于临床解释THI和TFI在耳管理中的得分.
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