现型化和内型化 儿科慢性鼻炎
Ella Morgan1, Michael J Cunningham1,2, Eelam A Adil1,2
1Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, USA.
概括
这项研究将儿科慢性鼻炎 (CRS) 分类为表型,发现eosinophilic CRS最常见和复发. 在儿童中,一个分类系统是可行的,有助于向治疗,尽管三分之一的儿童仍未被分类.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科过敏和免疫学
- 医学研究 医学研究
背景情况:
- 儿童慢性鼻炎 (CRS) 需要更好的分类来进行有针对性的治疗.
- 目前成人CRS的分类系统正在发展,但儿科特异性表型的定义较少.
研究的目的:
- 要将儿科慢性鼻炎 (CRS) 分为临床相关的初级和二级表型.
- 评估儿童CRS患者基于表型和内型的分类系统的可行性.
主要方法:
- 对94名患有CRS的儿科患者进行了回顾性图表审查,这些患者接受了内镜外科手术.
- 对临床,放射,实验室和手术内培养数据进行分析,以表型和内型特征.
主要成果:
- 乙性CRS是最常见的初级表型 (20.2%),与复发性疾病和修复手术相关.
- 其他确定的表型包括过敏性真菌鼻炎 (10.6%) 和带有囊性纤维化 (13.8%) 的CRS.
- 超过三分之一的患者 (38.2%) 无法根据目前的标准将其分类为特定的表型.
结论:
- 在儿科CRS中可以实现基于表型和内型的分类,类似于成人系统.
- 这种分类可以促进针对儿科CRS的向生物疗法的开发.
- 需要进一步的研究来确定大量未分类患者的病因.
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