主导干扰CARD11变异破坏JNK信号传递以促进T细胞中的GATA3表达

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Updated: May 21, 2025

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
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Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function

Published on: November 4, 2016

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Bradly M Bauman1,2, Jeffrey R Stinson1,2, Melissa A Kallarakal1

  • 1Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

The Journal of experimental medicine
|March 20, 2025
PubMed
概括

在CARD11蛋白信号传递中的缺陷会导致严重的阿托皮. 损坏的CARD11-JNK信号增强了T辅助2细胞的发育,通过增加GATA3表达,在患有CARD11相关的形与NF-κB信号 (CADINS) 疾病的主导干扰的患者.

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