在人类体内,循环的内分泌物中介和肠道微生物群组成的季节性变化
Sophie Castonguay-Paradis1,2,3, Élisabeth Demers-Potvin1,2, Gabrielle Rochefort1,2
1Centre Nutrition, santé et société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Québec, QC, Canada.
Gut microbes
|March 20, 2025
概括
季节性变化会影响肠道微生物群和内分泌物群,影响N-乙醇胺 (NAE) 和微生物家族. 这些变化与肠内可纳比因子群轴有关,独立于生活方式因素.
科学领域:
- 人类生理学 人类生理学
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群-内可纳素群轴对恒常状态至关重要,受到饮食和其他因素的影响.
- 之前的研究发现了季节性肠道微生物组变化,通常与饮食有关.
- 需要进行纵向研究,以隔离工业化人口中生活方式因素的季节性影响.
研究的目的:
- 纵向评估对人类肠道微生物组合的季节性影响.
- 为了研究循环内可纳比因组介质的季节性变化.
- 确定导致这些季节变化的因素.
主要方法:
- 在北克市对48人进行了纵向队列研究.
- 在冬季末和夏季收集血和便样本.
- 对饮食习惯,微生物群组成以及循环中的N-乙醇胺 (NAE) 和2-单糖醇 (2-MAG) 的分析.
主要成果:
- 在夏季末观察到更低的流通NAE.
- 肠道微生物群的转变包括Bifidobacteriaceae/Lachnospiraceae的减少和Bacteroidaceae/Ruminococcaceae的增加.
- 季节性变化独立于脂肪,饮食,体力活动和维生素D状况.
结论:
- 确定了肠道微生物群和NAE的季节性变化,独立于维生素D和生活方式.
- 突出了肠道微生物群-内可纳比诺基体轴在季节性病理生理学中的作用.
- 建议在涉及这些系统的临床试验中考虑季节性影响.
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