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Updated: May 21, 2025

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在MAPK8IP3中,一种有毒的功能增益变体提供了对JIP3细胞作用的洞察力

Wei Zhang1, Swapnil Mittal1, Ria Thomas1

  • 1n-Lorem Foundation, Carlsbad, California, USA.

JCI insight
|March 20, 2025
PubMed
概括

一种MAPK8IP3基因突变导致有毒的功能增长,破坏轴突运输,导致神经发育障碍. 反感性寡核酸有效降低细胞中的突变JIP3水平,提供了一个潜在的治疗策略.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.细胞生物学 细胞生物学遗传性疾病是一种遗传性疾病.遗传学 是一个遗传学.神经发育 神经发育治疗方法 治疗方法

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