健康和疾病中的微生物群,线粒体和表观遗传学:融合的途径来解决难题
Natalia Lucia Rukavina Mikusic1,2, Paula Denise Prince1,3, Marcelo Roberto Choi4,5
1Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET) CONICET, Universidad de Buenos Aires, 1122, Buenos Aires, Argentina.
Pflugers Archiv : European journal of physiology
|March 20, 2025
概括
肠道微生物组失衡 (失生症) 通过影响线粒体和表观遗传学,影响代谢健康. 针对肠道失调的干预措施可能有助于纠正线粒体功能障碍和表观遗传变化.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 线粒体生物学 线粒体生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 肠道微生物组成不平衡的肠道失调与2型糖尿病,肥胖和代谢综合征等代谢障碍有关.
- 精确的机制尚不清楚,但肠道微生物组,线粒体和表观遗传学之间的相互作用是相关的.
- 平衡的肠道微生物群对于线粒体功能和通过代谢产生的细胞健康至关重要.
研究的目的:
- 探索肠道微生物组,线粒体和表观遗传在代谢障碍中的相互关联的作用.
- 了解肠道失调如何影响线粒体功能和表观遗传修饰.
- 确定潜在的治疗策略,以肠道微生物群为代谢健康的目标.
主要方法:
- 关于肠道微生物组,线粒体功能和表观遗传学的当前科学文献的综述.
- 分析将微生物代谢物与线粒体活动联系起来的拟议机制.
- 检查线粒体和核表观基因组之间的双向通信.
主要成果:
- 肠道功能失调可以损害线粒体功能,导致能量代谢发生变化 (例如,糖分分解增加,氧化酸化减少) 和亡抵抗.
- 线粒体通过信号通路影响肠道微生物群的组成和功能.
- 来自线粒体的信号可以诱导核中的表观遗传变化,特别是在压力下.
结论:
- 在代谢健康的背景下,肠道微生物组,线粒体和表观遗传学是密切相关的.
- 肠道功能失调破坏了线粒体的功能,并引发了有害的表观遗传变化.
- 准肠道失调是一种有希望的治疗途径,可以缓解线粒体功能障碍和代谢障碍中的相关表观遗传变化.
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