在接受Takotsubo治疗的妇女中,心肌功能时间变化的前性比较与前部STEMI相比
Sandeep Jha1,2,3, Angela Poller1,4,3, Aaron Shekka Espinosa1,3
1Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
概括
在Takotsubo综合征 (TS) 和ST升高心肌梗塞 (STEMI) 的心脏功能恢复是相似的. 这项研究发现,TS患者与STEMI患者的左心室功能的恢复时间表相似.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 临床医学 临床医学
背景情况:
- 塔科苏博综合征 (TS) 和ST升高心肌梗塞 (STEMI) 分享可逆性急性心肌功能障碍的特征,称为心肌麻醉.
- 在TS和STEMI中心脏功能恢复的自然进展仍然不完全理解.
- 这项研究旨在比较患有TS的女性的心脏功能恢复与前部STEMI.
研究的目的:
- 为了前性地比较被诊断为Takotsubo综合征 (TS) 的女性心脏功能恢复的时间过程与前侧ST升高心肌梗塞 (STEMI).
- 为了评估可逆左心室动脉和关键心声学参数变化的解决方案在入院后30天.
主要方法:
- 塔科苏博的麻醉与急性心肌梗塞 (STAMI) 研究招募了61名TS患者和41名STEMI患者.
- 心声和血液采样是在多个时间点进行的,时间长达30天.
- 混合效应模型分析了心声回声学参数,主要结果是左室内动症在72小时内得到解决.
主要成果:
- 在72小时后,TS患者的可逆性无动症中,有40.4%的可逆性无动症消失,而STEMI患者的54.7%.
- 左心室喷射分数 (LVEF) 和全球纵向应变 (GLS) 的恢复轨迹在TS和STEMI组之间是相似的.
- 三环状平面缩外流 (TAPSE) 在TS中减少,但在STEMI中正常,恢复时间表类似.
结论:
- 心脏功能恢复的时间过程在塔科苏博综合征和STEMI之间是可比的.
- 在这两种情况中,心脏功能的显著恢复发生在治疗后7天以后.
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