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病中的脏参与:系统性审查和元分析

Astha Sethi¹, Tirlangi Praveen Kumar¹, Kutty Sharada Vinod²

¹Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

|March 20, 2025

概括

损伤是白螺旋病的常见并发症,影响近一半的患者. 这一系统性审查强调了急性损伤 (AKI) 的重大负担以及在流行地区需要更好的管理策略.

科学领域:

传染性疾病传染性疾病
腎臟病學 (nephrology) 是一種醫學專業.
公共卫生公共卫生

背景情况:

瘦素症构成了重大的公共卫生挑战,脏干扰是一个关键问题.
了解病患者病的患病率对于有效的管理和资源配置至关重要.

研究的目的:

在被诊断患有白病的患者中,系统地审查和元分析急性损伤 (AKI) 和慢性病 (CKD) 的频率.
量化AKI,寡尿症的综合发病率,以及在白血病病例中需要透析的情况.

主要方法:

一个全面的系统审查和对研究的元分析,发表到2024年8月14日,利用PubMed,Scopus和Web of Science.
纳入标准包括了关于白病和脏干扰的研究;数据提取和偏差风险评估由独立审稿人进行.
用随机效应模型估计了AKI,寡尿和透析的汇总率.

主要成果:

在白血病患者中,AKI的综合发病率为49.2%,尿量减少为31.5%,透析需求为14.4%.
在入院后观察到血清肌素 (3.6 mg/dl) 和尿素 (131.8 mg/dl) 水平升高.
在四项研究中,感染后新发性CKD的发病率范围广泛,从13%到62%.

结论:

急性损伤,寡尿症和透析的需要是白螺旋病的高度普遍的并发症.
与白螺杆菌病相关的病负担很大,需要在流行地区增加医疗保健资源,以改善患者的治疗结果.

关键词:

急性损伤是什么?急性损伤是什么?慢性脏疾病慢性脏疾病透析是通过透析进行的.莱普托斯皮罗斯症是什么?寡头主义 (Oliguria) 是一种

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Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.