预测单细胞药物敏感性使用适应权重特征多源域适应多源域适应
IEEE journal of biomedical and health informatics
|March 20, 2025
概括
这项研究引入了scAdaDrug,这是使用单细胞测序数据预测单个细胞药物反应的新模型. 它通过学习跨不同数据集的域不变特征来实现最先进的性能.
科学领域:
- 基因组学就是基因组学.
- 计算生物学 计算生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 单细胞测序产生了大量的转录数据,使得能够识别耐药瘤亚群.
- 目前的单细胞药物反应预测模型的性能不足于最佳.
- 开发准确的单细胞药物反应预测对于个性化癌症治疗至关重要.
研究的目的:
- 提出scAdaDrug,一个新的多源域适应模型,用于预测单个细胞对药物反应.
- 在单细胞水平上提高药物反应预测的准确性.
- 为了利用各种数据集进行强大的模型培训.
主要方法:
- 开发了scAdaDrug,这是一个多源域适应模型,利用适应性的重要意识表示学习.
- 采用了具有对抗域调整的共享编码器来提取域不变特征.
- 引入了一个plug-and-play模块,用于使用重要意识权重对潜伏表示进行自适应调制.
主要成果:
- 在多个独立数据集中,scAdaDrug 在药物反应预测方面取得了最先进的性能.
- 该模型在来自细胞系,患者衍生异体移植 (PDX) 和临床瘤队列的单细胞数据上表现出有效性.
- 废弃实验证实了该模型捕捉潜在药物反应模式的能力.
结论:
- scAdaDrug在单细胞药物反应预测方面取得了重大进展.
- 该模型的自适应性重要意识表示学习有效地整合了来自多个数据源的信息.
- scAdaDrug有望改善瘤学中的个性化治疗策略.
相关概念视频
00:42Cross-reactivity
Overview
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When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
01:25Dose-Response Relationship: Selectivity and Specificity
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...
01:24Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:16Drug toxicity: Idiosyncratic Reactions
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...