Anna Posfai1, Juannan Zhou1,2, David M McCandlish1

  • 1Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

PubMed
概括

我们开发了新的方法来固定定量序列函数模型中的"尺度自由",改进了对生物数据 (如DNA结合和蛋白质适应性) 的解释. 这允许更好地探索复杂的生物活动景观.

相关概念视频

Relating Angular And Linear Quantities - II01:05

Relating Angular And Linear Quantities - II

In the case of circular motion, the linear tangential speed of a particle at a radius from the axis of rotation is related to the angular velocity by the relation:
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Relating Angular And Linear Quantities - I01:09

Relating Angular And Linear Quantities - I

If the rotational definitions are compared with the definitions of linear kinematic variables from motion along a straight line and motion in two and three dimensions, we can observe a mapping of the linear variables to the rotational ones.
When comparing the linear and rotational variables individually, the linear variable of position has physical units of meters, whereas the angular position variable has dimensionless units of radians, as it is the ratio of two lengths. The linear velocity...
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Basic Discrete Time Signals01:16

Basic Discrete Time Signals

The unit step sequence is defined as 1 for zero and positive values of the integer n. This sequence can be graphically displayed using a set of eight sample points, showing a step function starting from n=0 and remaining constant thereafter.
The unit impulse or sample sequence is mathematically expressed as zero for all n values except at n=0, where it is one. The unit impulse sequence, denoted by δ(n), is the first difference of the unit step sequence, while the unit step sequence u(n) is...
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Per-Unit Sequence Models01:26

Per-Unit Sequence Models

An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
66
Numerical Calculations01:24

Numerical Calculations

In engineering applications, the representation of the numerical value is critical. Presenting or reporting the answer is one of the essential parts of engineering practices. Numerical calculations are performed using handheld calculators or computers since numerically accurate answers are always preferred.
The solution to a problem is obtained using different methods. While manually solving algebraic symbols is one of the most common methods, the graphical method is often preferred. Computers...
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Measurements of Strain01:27

Measurements of Strain

Strain quantifies the deformation of a material under force, typically measured as normal strain, which represents the change in length when compared with the original length. Electrical strain gauges are used for enhanced accuracy. These devices consist of a conductive wire mounted on a paper backing that adheres to the material's surface. These gauges operate on the piezoresistive effect, where the wire's electrical resistance changes in response to mechanical deformation. The strain...
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