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作为口腔状细胞癌的预后因素的LogODDS

Giada A Beltramini¹, Edoardo F Montrasio², Filippo Da Pozzo²

¹Maxillo-Facial Surgery and Dental Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.

Surgical oncology

|March 20, 2025

概括

在口腔状细胞癌患者中,LogODDS是整体生存的显著预后因素. 这一发现有助于根据复发风险对患者进行分层,补充了现有的分阶段系统.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
生物统计学生物统计学

背景情况:

口腔状细胞癌 (OCSCC) 构成了重大生存挑战.
准确的预后因素对于风险分层和治疗计划至关重要.
像TNM这样的现有分期系统可能会从增强的预测标记中受益.

研究的目的:

评估LogODDS在OCSCC患者的整体生存期 (OS) 和无病生存期 (DFS) 中的预后作用.
确定一个LogODDS截止值,用于将OCSCC患者分为高和低复发风险组.
将LogODDS与淋巴结比率 (LNR) 和TNM第8版集成,以改善预后.

主要方法:

74名经过手术转移淋巴结的OCSCC患者的回顾性分析.
计算LogODDS和淋巴结比率 (LNR).
根据TNM第八版的标准进行了重新排列.
多变量分析以评估OS和DFS的预后意义.

主要成果:

在多变量分析中,LogODDS和LNR是总生存 (OS) 的统计学显著预测因素.
单独的N类别对于OS预测没有达到统计学意义.
没有一个评估的参数在预测无病生存期 (DFS) 中显示出统计相关性.

结论:

LogODDS是预测口腔状细胞癌的整体存活率的令人信服的预后因素.
LogODDS可以增强OCSCC患者的风险分层,特别是与LNR和TNM分期相结合时.

关键词:

在LogODDS中使用LogODDS 淋巴结比率是淋巴结的比率.口腔癌是一种口腔癌.口腔状细胞癌的癌症.预测因素预测因素

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