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细菌中广泛的抗生素异种耐受性仍然未被耐药性测试检测到

Bram Van den Bergh¹, Philip Ruelens¹, Lieze Agten¹

¹Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, KU Leuven, Belgium; Center for Microbiology, Vlaams Instituut voor Biotechnologie, VIB-KU Leuven, Belgium.

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概括

抗微生物药物耐药性是一个主要的威胁,一种称为异种耐受性的现象通常被标准测试遗漏. 需要新的诊断策略来改善患者治疗结果.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
临床诊断临床诊断临床诊断

背景情况:

抗菌素耐药性 (AMR) 仍然是一个重大的全球卫生挑战.
超出传统耐药性的机制,如异种耐药性,有助于抗生素治疗失败.
目前的诊断主要集中在最小抑制度 (MIC) 上,可能会忽视影响药物有效性的其他因素.

研究的目的:

调查临床细菌菌株中异种耐受性的流行情况.
突出基于MIC的诊断在捕捉抗生素反应的全谱方面的局限性.
倡导采用包含耐受性数据的新型诊断方法,以改善患者管理.

主要方法:

临床细菌分离物进行了异种耐受性测试.
分析了1000多种临床菌株的大队列.
与传统的基于MIC的敏感性测试相比,异性耐受性患病率的比较.

主要成果:

在大量临床菌株中检测到广泛的异种耐受性.
异种耐受性在很大程度上没有被标准的基于MIC的诊断方法检测出来.
这些发现表明,目前的诊断能力存在重大差距.

结论:

仅仅抗微生物耐药性是预测治疗成功的不足.
异种耐受性是一种常见的现象,会影响抗生素的有效性.
开发新的诊断测试和结合耐受性数据的临床策略对于改善感染性疾病患者的治疗结果至关重要.

关键词:

抗菌药物反症 (AMR) 是一种抗生素耐受性抗生素耐受性异种耐受性异种耐受性坚持不坚持不电阻电阻电阻电阻电阻电阻

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