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Updated: May 21, 2025

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
09:30

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

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通过单个纳米粒子跟踪,在单个分子层面检测异质结合事件.

Yi Wang1, Liting Qi1, Le Sun1

  • 1State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.

Talanta
|March 20, 2025
PubMed
概括

这项研究介绍了一种单分子传感平台,使用纳米粒子跟踪来检测生物标志物. 它实现了神经元特异性酶的低检测极限,并将特异性与非特异性结合事件区分开来.

关键词:
距离取决于扩散速度的扩散速度.光学成像技术的使用.单个纳米粒子计数计算单个纳米粒子映射绘制单分子生物感应生物感应.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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