在胃肠道癌症中的分子瘤板
L Boscolo Bielo1, E Crimini1, M Repetto2
1Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy.
ESMO open
|March 20, 2025
概括
分子瘤板 (MTBs) 改善了胃肠道 (GI) 癌症的治疗决策. 对分子导向治疗选择 (MGTO) 的MTB建议显示,晚期肠胃癌患者的无进展生存率有所改善.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 综合基因组分析 (CGP) 越来越多地用于分子引导治疗选择 (MGTO).
- 建立了分子瘤委员会 (MTB),以优化MGTO在癌症治疗中的整合.
- 关于胃肠道 (GI) 癌症中MTBs的临床价值的数据有限.
研究的目的:
- 评估MTBs在指导晚期肠胃癌治疗决策中的临床价值.
- 评估MTB推的MGTO对患者结局的影响.
- 使用现实世界无进展生存率 (rwPFS) 和生长调节指数 (GMI) 来量化治疗的有效性.
主要方法:
- 在MTB (2019年8月 - 2024年12月) 上讨论了晚期肠胃癌患者的回顾性分析.
- 根据MTB建议,对接受MGTO与标准治疗的患者的临床结果的评估.
- 计算rwPFS,总生存期 (OS) 和GMI以评估治疗的有效性.
主要成果:
- 192名胃肠道癌患者中有139名 (72.3%) 接受了MTB治疗建议.
- 31名患者 (17.7%) 接受了MGTO,与标准疗法 (3.55个月) 相比,他们显示了较长的rwPFS (5.35个月) 和未接受治疗的患者具有可操作的生物标志物 (2.40个月).
- ESCAT I-III级治疗产生了4.87个月的PFS增长;没有观察到显著的OS差异.
结论:
- 基于MTB的决策为晚期胃肠道癌患者提供临床益处.
- 通过MGTO,MTB可以扩大治疗选择.
- 这项研究支持将MTB纳入常规胃肠道癌症护理.
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