由SARS-CoV-2 KP.3亚变体引起的第11波的特征:肺炎严重程度的再次增加
Naoyuki Miyashita1, Yasushi Nakamori2, Makoto Ogata1
1First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.
与XBB和JN.1相比,KP.3 Omicron亚型导致更严重的肺炎,需要进入重症监护室 (ICU) 或侵入性机械通风 (IMV). 年龄和并发症增加了严重性风险.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- SARS-CoV-2的Omicron变种已经演变为众多子变种,影响疾病严重程度和临床结果.
- 肺炎仍然是COVID-19的重要并发症,与不同Omicron亚系相关的风险有所不同.
研究的目的:
- 确定由SARS-CoV-2 Omicron亚型引起的肺炎患者的重症监护室 (ICU) 或侵入性机械通风 (IMV) 住院的发病率和风险因素.
- 为了比较与不同Omicron亚型相关的肺炎的严重程度,特别是XBB,JN.1和KP.3.
主要方法:
- 对536名因SARS-CoV-2 Omicron亚变种被诊断患有肺炎的患者进行了回顾性分析.
- 根据特定的亚变种对患者进行分类:XBB血统 (175例),JN.1 (169例) 和KP.3 (192例).
主要成果:
- 与XBB或JN.1亚变体相比,感染KP.3亚变体的患者的ICU入院率或需要IMV的比例显著更高.
- 肺炎严重程度增加的重要风险因素包括患者的晚年 (OR: 1.09),免疫缺陷 (OR: 2.82),两种或更多的并发病 (OR: 2.54) 和自上次接种疫苗以来的时间超过两年 (OR: 1.29).
结论:
- KP.3亚变体对严重的肺炎结果的风险更大,需要进行重症监护干预.
- 建议包括优先进行SARS-CoV-2疫苗接种,以及对老年患者 (≥65岁) 和患有多种并发症的患者明智使用抗SARS-CoV-2疗法.
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