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快速识别高风险的B型大动脉剖析人群:血液动力学研究

Haoyue Xu¹, Chengxin Weng², Da Li³

¹Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; West China School of Medicine, Sichuan University, Chengdu 610041, China.

Journal of biomechanics

|March 20, 2025

概括

一种新的,临床医生友好的方法可以快速计算血管壁上的血液力 (BFVW),通过识别患者中较高的BFVW大小和改变方向,帮助早期检测胸前动脉瘤和剖析 (TBAD).

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
医学成像分析医学成像分析

背景情况:

计算流体动力学 (CFD) 是计算血管壁上的血液力 (BFVW) 的标准,但需要专门的专业知识.
胸前动脉瘤和解剖 (TBAD) 是一种严重的疾病,了解BFVW对于风险评估至关重要.
需要一种更快,更容易使用的方法来计算BFVW,特别是在易受TBAD影响的地区.

研究的目的:

开发和验证一种用于快速计算BFVW的新型非数值方法.
调查计算的BFVW与TBAD发生之间的关联.
评估早期TBAD风险识别新方法的临床实用性.

主要方法:

一种基于动量定理的临床医生友好的方法被开发出来,用于计算BFVW.
这种新方法在30名高风险TBAD患者和30名健康对照中与传统的CFD模拟进行了验证.
分析了特定于患者的BFVW大小和方向,并在各组之间进行了比较.

主要成果:

在BFVW计算的拟议方法和CFD之间观察到良好的一致性 (R > 0.98).
与健康对照组 (15.37 N ± 3.08 N,P < 0.01) 相比,TBAD患者的BFVW幅度显著增加 (23.22 N ± 5.64 N).
在TBAD患者和对照人群中,BFVW方向有显著的差异,与垂直的角度相比,TBAD患者与对照人群的角度更大 (P < 0.01).

结论:

拟议的非数值方法提供了一个快速,准确和可访问的方法来计算患者特定的BFVW.
升高的BFVW和改变的方向与TBAD有关,表明作为生物标志物的潜力.
这种方法可以帮助临床医生早期识别患有TBAD风险的个体,并为血压管理策略提供信息.

关键词:

计算流体动力学计算流体动力学动量定理动量定理个性化血压管理个性化血压管理乙型大动脉剖析乙型大动脉剖析

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