艾米卡辛及其组合抗生素在7.5%的伊科德克斯腹腔透析溶液中的稳定性和兼容性
Haishan Wu1,2, Pengchao Fang3, Zhihao Liu4
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, wuhshan@mail2.sysu.edu.cn.
一些抗生素,包括西普罗撒和阿米卡,在伊科德克斯腹膜透析溶液中稳定长达14天. 这些抗生素,特别是阿米卡辛组合,适用于治疗PD相关的腹膜炎.
科学领域:
- 制药科学 制药科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药房 临床药房
背景情况:
- 腹膜炎是腹膜透析 (PD) 的重要并发症.
- 抗生素在PD溶液中的稳定性对于有效治疗至关重要.
- 7.5%的冰烯溶液用于PD,但抗生素兼容性需要评估.
研究的目的:
- 为了评估各种抗生素在7.5%的伊科德克斯特林PD溶液中的稳定性和兼容性.
- 为了确定抗生素在14天的不同温度条件下的稳定性.
主要方法:
- 五种抗生素 (阿米卡辛,阿米皮涅姆,西普罗夫洛克萨辛,万科米辛,塞法索林) 添加到7.5%的冰素溶液中.
- 样品在各种温度下 (4°C,25°C,37°C) 保存长达14天.
- 使用高性能液体色谱测量了抗生素度;稳定性被定义为>90%的剩余度.
主要成果:
- 在所有测试温度下,西普罗夫洛克萨和阿米卡在14天内保持稳定.
- 阿米卡辛与万科米辛,塞法索林或西普罗夫洛克萨辛的组合在14天内保持稳定.
- 范科米辛在4°C和25°C下稳定了14天,但在37°C下稳定了7天. 塞法林的稳定性有限 (37°C时8小时). 伊米胺的稳定性很低 (4°C最大6小时).
结论:
- 齐普罗夫洛克萨和阿米卡在伊科德克斯特林溶液中稳定,适用于PD相关的周周炎治疗.
- 阿米卡辛与万科米辛,塞法索林或西普罗夫洛克萨辛的组合也在常规储存温度下至少稳定7天.
- 这些发现支持使用特定的抗生素-icodextrin添加剂用于PD周周炎的管理.
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