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Updated: May 21, 2025

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death
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由胰岛素mRNA加速衰变引起的1型糖尿病的遗传保护

René van Tienhoven1, Denis O'Meally2, Tristan A Scott3

  • 1Department of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands.

Cell
|March 20, 2025
PubMed
概括

一种特定的胰岛素基因变异 (INSP) 通过加速胰岛素mRNA衰变,改善β细胞功能和移植结果.

关键词:
紧急救护室的压力贝塔细胞的功能有缺陷的核糖体产物遗传风险免疫耐受性免疫性胰岛素基因新抗原一类糖尿病不折叠的蛋白质反应

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