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相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

473
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
473
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

700
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
700
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

738
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
738
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

430
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
430
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

620
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
620

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相关实验视频

Updated: May 21, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

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人类免疫细胞中的亚洲多样性

Kian Hong Kock1, Le Min Tan1, Kyung Yeon Han2

  • 1Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A(∗)STAR), 60 Biopolis Street, Genome, Singapore 138672, Singapore.

Cell
|March 20, 2025
PubMed
概括

亚洲免疫多样性图谱 (AIDA) 揭示了亚洲的多样性,年龄和性别如何影响免疫细胞的特性. 这本单细胞参考地图书为不同亚洲人群提供了精准医学.

关键词:
在 eQTL遗传多样性遗传学基因组学健康的基线人类的多样性免疫细胞精准医学单细胞RNA测序亚洲地区的多样性

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Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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相关实验视频

Last Updated: May 21, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

12.9K
Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
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Published on: September 19, 2013

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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科学领域:

  • 免疫学
  • 基因组学
  • 人口健康

背景情况:

  • 人类多样性与生物医学特征的联系很重要,但在单细胞基因组学中还没有得到充分研究.
  • 缺少亚洲免疫细胞的综合参考地图.

研究的目的:

  • 创建亚洲免疫多样性图谱 (AIDA),这是一个单细胞RNA测序健康人体免疫细胞的参考图谱.
  • 研究亚大陆多样性,年龄和性别对免疫细胞特性的影响.
  • 确定影响不同亚洲人群免疫细胞基因表达的功能遗传变异.

主要方法:

  • 来自7个亚洲人群的619个捐赠者的1,265,624个循环免疫细胞的单细胞RNA测序 (scRNA-seq).
  • 对差异性细胞丰度,基因表达和细胞邻域的分析.
  • 影响细胞类型特异性基因表达的功能遗传变异的识别和语境化.

主要成果:

  • 亚大陆的多样性,年龄和性别显著影响了免疫细胞的丰富性,基因表达和细胞社区.
  • 发现了影响细胞类型特定基因表达的功能基因变异,其中一些在非亚洲人群中代表性不足.
  • 在多种祖先数据集中,AIDA为了解免疫细胞变异和疾病关联提供了宝贵的资源.

结论:

  • 亚洲免疫多样性图谱 (AIDA) 强调了微粒度的人类多样性对免疫细胞特征的普遍影响.
  • 通过提供对遗传变异及其对亚洲人群免疫反应的影响的见解,AIDA促进了精准医学.
  • 这本地图书是多种祖先疾病研究和有针对性的健康干预措施开发的重要资源.