人类免疫细胞中的亚洲多样性
Kian Hong Kock1, Le Min Tan1, Kyung Yeon Han2
1Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A(∗)STAR), 60 Biopolis Street, Genome, Singapore 138672, Singapore.
Cell
|March 20, 2025
概括
亚洲免疫多样性图谱 (AIDA) 揭示了亚洲的多样性,年龄和性别如何影响免疫细胞的特性. 这本单细胞参考地图书为不同亚洲人群提供了精准医学.
科学领域:
- 免疫学
- 基因组学
- 人口健康
背景情况:
- 人类多样性与生物医学特征的联系很重要,但在单细胞基因组学中还没有得到充分研究.
- 缺少亚洲免疫细胞的综合参考地图.
研究的目的:
- 创建亚洲免疫多样性图谱 (AIDA),这是一个单细胞RNA测序健康人体免疫细胞的参考图谱.
- 研究亚大陆多样性,年龄和性别对免疫细胞特性的影响.
- 确定影响不同亚洲人群免疫细胞基因表达的功能遗传变异.
主要方法:
- 来自7个亚洲人群的619个捐赠者的1,265,624个循环免疫细胞的单细胞RNA测序 (scRNA-seq).
- 对差异性细胞丰度,基因表达和细胞邻域的分析.
- 影响细胞类型特异性基因表达的功能遗传变异的识别和语境化.
主要成果:
- 亚大陆的多样性,年龄和性别显著影响了免疫细胞的丰富性,基因表达和细胞社区.
- 发现了影响细胞类型特定基因表达的功能基因变异,其中一些在非亚洲人群中代表性不足.
- 在多种祖先数据集中,AIDA为了解免疫细胞变异和疾病关联提供了宝贵的资源.
结论:
- 亚洲免疫多样性图谱 (AIDA) 强调了微粒度的人类多样性对免疫细胞特征的普遍影响.
- 通过提供对遗传变异及其对亚洲人群免疫反应的影响的见解,AIDA促进了精准医学.
- 这本地图书是多种祖先疾病研究和有针对性的健康干预措施开发的重要资源.
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