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Updated: May 21, 2025

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在BRD4位点中的反复发生的断点减少了与基因放大相关的毒性

Jeremiah Wala1, Simona Dalin1, Sophie Webster1

  • 1Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell genomics
|March 20, 2025
PubMed
概括

在BRD4基因中经常发生的删除会破坏其调节,影响癌症的进展. 通过这些删除来微调BRD4水平,可以从毒性中拯救癌细胞,从而揭示出一种新的癌症机制.

关键词:
这就是BRD4D.克里斯普尔-Cas9是什么意思这是一个PCAWG财团.乳腺癌 乳腺癌 乳腺癌基因放大 基因放大 基因放大基因异型的基因异型.卵巢癌是发生在卵巢的癌症.结构变体 结构变体有毒的基因 有毒的基因

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