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复杂的Roux-en-Y后胃绕道患者的口服可纳吸收:一个病例报告
Diana R Langworthy1, Jennifer K Ross2
1Department of Pharmaceutical Care and Health Systems, University of Minnesota College of Pharmacy, Minneapolis, MN, USA.
Journal of pharmacy practice
|March 20, 2025
概括
口服可纳在经过Roux-en-Y胃绕道 (RYGB) 的患者中显示出高的生物可用性. 这一发现对于优化抗真菌疗法在有腹手术史的个人中至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 由于胃的限制和吸收不良,Roux-en-Y胃绕道 (RYGB) 改变了药物的吸收.
- 关于优化口服药物的数据有限,包括抗真菌药物,RYGB后.
- 可纳是一种广泛使用的抗真菌药物,具有很高的口服生物可用性.
研究的目的:
- 在有RYGB病史的患者中调查口服可纳的生物可用性.
- 评估RYGB对可纳吸收和疗效的影响.
主要方法:
- 一个患有RYGB和持久性候选血病的病例研究.
- 静脉注射 (IV) 和口服治疗期间稳定状态谷水平的比较.
- 在潜在的胃肠道并发症的背景下监测药物水平.
主要成果:
- 口服可纳达到 44.4 微克/毫升的平稳状态最低水平.
- 静脉输入的可纳达到41.9微克/毫升的稳定状态最低水平.
- 这些水平表明RYGB后口服和静脉输入途径之间的可比生物利用性.
结论:
- 口服可纳在RYGB.患者中保持了高的生物可用性.
- 可纳的线性药理动力学表明,吸收减少与较低的低谷水平相关.
- 医疗保健提供者应保持警,在胃绕道术后评估药物疗效.
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