来自天然深层阳性溶剂的Alkanna tinctoria (L.) 的Hydroxynaphthoquinone Enantiomers的回收技术:比较分析
Elodie Bossard1, Nikolaos Tsafantakis1, Nektarios Aligiannis1
1Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Planta medica
|March 20, 2025
概括
天然的深溶性溶剂提供了一种绿色替代品,用于提取氧纳丁 (HNQs) 的反体. 固相提取产生了最高的HNQ回收,而宏树脂被证明对大规模应用和溶剂回收有效.
科学领域:
- 绿色化学 绿色化学
- 自然产品提取 提取自然产品
- 植物化学 植物化学
背景情况:
- 天然深层环氧溶剂 (NaDES) 正在成为传统有机溶剂的可持续替代品.
- 基于levulinic酸和葡萄糖的NaDES (LeG_5_20) 显示出提取有价值的化合物,如氧纳丁酶体 (HNQs) 的前景.
- 纳德斯的一个主要挑战是它们的低波动性,需要有效的回收方法.
研究的目的:
- 研究和比较使用NaDES提取Alkanna tinctoria根的HNQ的不同方法.
- 评估固相提取 (SPE),宏孔树脂吸附和抗溶剂沉对HNQ回收的适用性.
- 评估最有前途的恢复方法的可扩展性和绿色凭据.
主要方法:
- 从Alkanna tinctoria根中提取HNQ,使用基于酸-葡萄糖的NaDES (LeG_5_20).
- 使用C8逆相SPE,Amberlite XAD 4巨孔树脂和水作为抗溶剂,对HNQ回收的比较分析.
- 对NADES的扩展潜力,稳定性和可回收性进行评估,以选择回收方法.
主要成果:
- 在C8弹上进行固体相提取,实现了最高的HNQ回收,总纳夫托基含量 (TNC) 为46.79±0.952 mg/g DW.
- 安伯莱特XAD 4巨孔树脂提供了良好的回收 (37.21±1.789 mg/g DW) 并显示出大规模应用的潜力.
- 使用Amberlite XAD 4的扩展过程显示了高效的HNQ回收 (34.126 ± 1.093 mg/g DW),并使NaDES回收 (>50%的回收) 成为可能.
结论:
- 固相提取是从NADES提取物中恢复HNQ的最有效方法.
- 安伯莱特XAD 4宏树脂为大规模的HNQ提取和NaDES回收提供了可行的绿色选择.
- 开发的基于NaDES的提取和回收过程为获得HNQ的传统方法提供了可持续的替代方案.
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