在健康的衰老中,听力和认知障碍的白质完整性
Samaneh Nemati1, Meisam Arjmandi1, Jean Neils-Strunjas1
1Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
NeuroImage
|March 20, 2025
概括
与年龄相关的听力损失与认知能力下降有关. 这项研究发现,较差的白质完整性与听力和认知功能受损相关,特别是在特定的大脑区域.
科学领域:
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
- 听觉神经科学 听觉神经科学
背景情况:
- 年龄相关听力损失 (ARHL) 影响许多老年人,并与认知能力下降和痴呆风险有关.
- 了解ARHL的神经基础及其与认知功能的关系对于健康的衰老至关重要.
研究的目的:
- 研究白质完整性与健康老年人听力和认知功能之间的关联.
- 探索扩散张力成像 (DTI) 在识别与听觉和认知障碍相关的微观结构变化的实用性.
主要方法:
- 从老化大脑队列研究中招募了126名参与者 (20-79岁).
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能,并通过纯音和单词噪音值听力.
- 测量白质完整性使用DTI指标 (微分异型和平均扩散性) 并分析与听力和认知分数的关系.
主要成果:
- 较低的分数异构性 (FA) 和较高的平均扩散性 (MD) 与较差的听力和认知表现显著相关.
- 这些关联在前/上冠状辐射体,体和上纵囊中突出.
- 与没有听力障碍的老年人相比,在几个大脑区域中显示出显著的MD差异.
结论:
- 白质完整性与健康衰老中的听力和认知功能密切相关.
- DTI揭示了与听力障碍相关的大脑中的微观结构变化.
- DTI是研究老年人听力和认知衰退的神经基础的宝贵工具.
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