精神分裂症谱系障碍中的神经软征兆和甲状腺激素
Michael Carl Treiber1, Eva-Maria Tsapakis2, Sophia Athanasiou2
13rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; Divison of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria; Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Austria.
Progress in neuro-psychopharmacology & biological psychiatry
|March 20, 2025
概括
较低的自由甲状腺素 (fT4) 水平与精神分裂症谱系障碍 (SSD) 的男性的神经软征兆 (NSS) 相相关. 甲状腺激素 (TH) 和NSS需要在SSD进行进一步的研究,以了解神经发育的联系.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 神经软征兆 (NSS) 代表与神经发育障碍和精神分裂症谱系障碍 (SSD) 相关的微妙感官和运动缺陷.
- 甲状腺激素 (TH) 在神经发育中起着至关重要的作用,它们的改变与SSD有关,但NSS和TH之间的具体关系尚不清楚.
研究的目的:
- 在被诊断为SSD的个体中调查NSS和甲状腺激素水平之间的关联.
- 探索NSS,甲状腺激素水平 (TSH,ft4,ft3) 和SSD患者心理病理之间的潜在相关性.
主要方法:
- 该研究包括72名SSD患者,通过神经评估量表 (NES) 评估NSS,通过正负综合征量表 (PANSS) 评估临床症状.
- 测量了甲状腺刺激激素 (TSH),自由甲状腺素 (fT4) 和自由三甲状腺素 (fT3) 的血清水平.
- 统计分析包括性别差异的t测试和Pearson相关性,以检查NSS,TH和精神病理学之间的关系,按性别分层.
主要成果:
- 在SSD患者中,在血清自由甲状腺素 (fT4) 和总NES得分 (r = -0.374,p = 0.032) 和"感官整合"子域 (r = -0.372,p = 0.033) 之间发现了显著的负相关性.
- 在控制年龄,DOI和抗精神病剂量 (r = -0.424,p = 0.049) 之后,fT4和感官整合之间的这些相关性仍然显著.
- 血清fT3或TSH和NES得分之间没有明显的相关性,尽管ft3和PANSS负症状得分之间存在负相关性 (r = -0.472,p < 0.001).
结论:
- 较低的ft4水平与NSS严重程度增加和特定的NSS缺陷有关,特别是在SSD的男性个体中.
- 在总样本中观察到fT3和负症状之间的显著负相关性.
- 未来的研究应该专注于更大的,以前没有使用过药物的SSD队列,并进行纵向跟踪以确定因果关系.
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