与常规摄入量相比,果摄入改善了成年人心脏代谢疾病风险增加的脂蛋白颗粒度:随机对照试验
Tricia L Hart1, Penny M Kris-Etherton1, Kristina S Petersen1
1Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, United States.
The Journal of nutrition
|March 20, 2025
概括
每天食用坚果果显著改善了心脏代谢疾病风险的成年人中的脂蛋白亚分数和胰岛素抵抗标志物. 用 pecans 取代零食对阿波利波蛋白 B 和异性质颗粒产生了积极影响.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 代谢性疾病研究研究
背景情况:
- 众所周知,坚果果的摄入量可以改善整体脂蛋白.
- 关于 pecans 对脂蛋白分片的特定影响的研究有限.
- 心脏代谢疾病的风险需要了解饮食对脂质资料的影响.
研究的目的:
- 为了研究每天用57克的 pecans 代替通常的零食对12周内脂蛋白分片和非脂蛋白的影响.
- 为了比较这些效应与持续的通常零食摄入量.
- 探索 pecans 对早期胰岛素抵抗标志物的影响,包括脂蛋白胰岛素抵抗指数 (LP-IR).
主要方法:
- 这是一项为期12周的随机并行试验,涉及有心脏代谢疾病风险的成年人.
- 参与者被分配每天消费57g的 pecans,而不是零食,或者保持通常的摄入量.
- 使用质子核磁共振光谱分析的血样本用于脂蛋白,阿波脂蛋白和GlycA;通过线性回归评估差异.
主要成果:
- 坚果群体显示,阿波利波蛋白B (apoB),总低密度脂蛋白颗粒和富含甘油三蛋白脂蛋白颗粒 (TRL-P) 的显著减少.
- 观察到大和小TRL-P的具体减少,以及脂蛋白胰岛素抵抗指数 (LP-IR) 的下降.
- 与通常饮食组相比,果仁组也经历了大型高密度脂蛋白颗粒的增加.
结论:
- 在12周内每天加入57g的 pecans 作为零食替代品,改善了危险成年人的apoB,动脉动脉脂蛋白亚分数和LP-IR.
- 这种饮食修改为控制心脏代谢风险因素提供了潜在的策略.
- 该试验已在clinicaltrials.gov注册,名为NCT05071807.
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