过敏反应 纤维素粘合剂在腹膜外血补丁期间的过敏反应
Jennifer L Smith1, Myoung J Kim1, Linda Gray1
1From the Departments of Radiology (J.L.S., M.J.K., L.G., M.D.M., P.G.K., T.J.A.), Duke University Medical Center, Durham, North Carolina.
AJNR. American journal of neuroradiology
|March 20, 2025
概括
在 epidural blood patching (EBP) 过程中对纤维素的过敏反应发生在0.49%的手术中. 年轻的患者,较低的BMI和静脉注射增加风险,在第一次暴露时没有反应.
科学领域:
- 神经外科 神经外科
- 麻醉学 麻醉学
- 放射学 放射学是一门学科.
背景情况:
- 纤维素越来越多地用于脊髓脑脊髓液 (CSF) 泄漏的外周血补丁 (EBP).
- 对纤维素的过敏反应是EBP的潜在并发症,但没有充分记录.
研究的目的:
- 为了确定EBP期间对纤维素的过敏反应的发生率.
- 确定与这些反应风险增加相关的患者和程序因素.
主要方法:
- 一项以嵌套病例对照设计的回顾性队列研究分析了3065个CT引导EBP与纤维素合剂超过13年.
- 包括接受纤维素EBP治疗的患者,以治疗中枢神经液泄漏或自发性内低血压.
- 后勤回归模型确定了患者人口统计学,程序变量和过敏反应之间的关联.
主要成果:
- 过敏反应的发生率为每次手术的0.49%和每位患者的0.95%.
- 在患者第一次使用纤维素粘合剂进行EBP时,从未出现过反应.
- 较高的反应几率与较低的BMI (OR 0.82),年轻的年龄 (OR 0.95) 和无意中静脉注射 (OR 5.44) 相关.
结论:
- 纤维素粘合剂EBP的过敏反应发病率低 (0.49%),在初次暴露时没有反应.
- 年轻的年龄,较低的BMI和无意中IV注射是过敏的危险因素.
- 结果有助于患者咨询和医生意识,以防止不良反应.
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