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在肺癌中,PD-L1表达和[F]FAPI与[F]FDG吸收在PET/CT上的关系

Jingjie Qin¹, Chao Han^2,3, Haoqian Li¹

¹Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, No. 440 Jiyan Road, Jinan, Shandong, 250117, China.

European journal of nuclear medicine and molecular imaging

|March 21, 2025

概括

纤维细胞激活蛋白抑制剂 (FAPI) PET/CT与肺癌中编程死亡配体1 (PD-L1) 表达呈正相关性,这表明其在预测免疫治疗反应方面的潜力.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
免疫治疗是一种免疫疗法.

背景情况:

肺癌的诊断和治疗依赖于准确的生物标志物.
编程死亡配体1 (PD-L1) 表达是免疫治疗反应的关键预测因子.
需要新的成像技术来非侵入性地评估PD-L1表达.

研究的目的:

为了研究[18F]标记的纤维细胞激活蛋白抑制剂 (FAPI) 定子发射断层扫描/计算机断层扫描 (PET/CT) 吸收和肺癌中的PD-L1表达之间的相关性.
为了评估[18F]FAPI PET/CT对PD-L1表达的预测值,与[18F]氧葡萄糖 ([18F]FDG) PET/CT相比.

主要方法:

在75名接受[18F]FAPI和[18F]FDG PET/CT的肺癌患者进行了回顾性研究.
通过免疫组织化学评估PD-L1表达,并分为三组.
从PET/CT扫描中分析瘤与背景比率 (TBR) 和与PD-L1水平的相关性.

主要成果:

[18F]FAPI PET/CT瘤与背景比率 (肺TBR和血液TBR) 与PD-L1表达正相关 (r=0.32,P<0.01;r=0.26,P<0.05).
在高PD-L1表达的病例中观察到更高的[18F]FAPI吸收.
[18F]FDG PET/CT与PD-L1表达没有显著的相关性.

结论:

[18F]FAPI吸收与肺癌中的PD-L1表达有正相关.
[18F]FAPI PET/CT可以作为PD-L1表达的非侵入性生物标志物.
将[18F]FAPI PET/CT与PD-L1评估结合起来可以提高肺癌免疫疗法反应预测.

关键词:

纤维细胞激活蛋白质的激活蛋白质肺癌是一种肺癌.在 PD-L1 表达式上.聚乙烯/聚乙烯/聚乙烯

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