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关于ECMO管相关感染的特征和结果:欧洲多中心回顾性研究
Sofia Ortuno1, Nicolas Massart2, Charles Vidal3
1Service de Médecine Intensive-Réanimation, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, 47-83, Boulevard de L'Hôpital, 75651, Paris Cedex 13, France.
与ECMO管相关的感染 (ECMO-CRIs) 通常是多微生物的,与血液感染有关. 较短的抗生素疗程 (≤8天) 对于ECMO-CRIs似乎是安全的,显示出类似的复发率和死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 医疗设备感染 医疗设备感染
背景情况:
- 关于体外膜氧化 (ECMO) 管相关感染 (ECMO-CRIs) 的流行病学和管理的数据有限.
- 了解这些感染对于改善重症监护机构患者治疗结果至关重要.
研究的目的:
- 描述ECMO-CRIs的流行病学和预后.
- 在ECMO-CRIs中识别与患者结果相关的因素.
- 评估抗微生物治疗持续时间对ECMO-CRI结果的影响.
主要方法:
- 在12个欧洲重症监护病房 (ICU) 进行了一项多中心回顾性研究.
- 包括的患者在临床上怀疑ECMO-CRI,ECMO管部位的细菌样本呈阳性.
- 收集的数据包括感染特征,复发率,危险因素和抗微生物治疗持续时间.
主要成果:
- 分析了109名ECMO-CRI患者,其中42%的发作是多微生物.
- 肠杆菌科,凝固酶阴性葡萄球菌和肠球菌 spp. 是最常见的病原体.
- 在ICU的死亡率为51%,同时血液感染和败血症休克是死亡的危险因素. 复发率为13%. 这些病例的复发率为13%.
结论:
- ECMO-CRI经常是多微生物的,并且与血液感染有关.
- 与较长时间相比,长达8天或更短的抗菌疗程似乎不会增加复发或死亡风险.
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