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Updated: May 21, 2025

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
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Published on: August 10, 2012

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通过J-域蛋白DNAJC12的结构识别和稳定氨酸氧酶

Mary Dayne S Tai1,2, Lissette Ochoa3, Marte I Flydal1,4

  • 1Department of Biomedicine, University of Bergen, Bergen, Norway.

Nature communications
|March 21, 2025
PubMed
概括

DNAJC12蛋白中的致病变体通过破坏其与氨酸氧酶 (TH) 的相互作用引起帕金森症. DNAJC12结合稳定TH,防止聚合并保持多巴胺的产生.

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