在精神分裂症患者中常见和独特的白质分数异构模式,具有抗药性听觉语言幻觉:基于通道的回顾性空间统计研究
Chuanjun Zhuo1,2, Chao Li3,4, Xiaoyan Ma3,4
1Computational Biology and Animal Imaging Center (CBAC), Tianjin Anding Hospital, Nankai University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Mental Health Center, Tianjin, 300222, China. chuanjunzhuotjmh@163.com.
精神分裂症患者有听觉语言幻觉 (AVHs) 显示出明显的白质 (WM) 管道差异. 这些白质异常在耐药和可治疗的AVH之间存在差异,影响治疗的有效性.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 白色物质 诚信 诚信
背景情况:
- 听觉口头幻觉 (AVHs) 影响大多数精神分裂症患者,并且经常抵抗抗精神病治疗.
- 白质 (WM) 管道异常与AVH治疗精神分裂症的疗效有关.
研究的目的:
- 调查精神分裂症患者的白质 (WM) 管道完整性差异与耐药与可治疗的听觉语言幻觉 (AVHs).
- 为了在患者组和健康对照组之间比较5年抗精神病治疗的WM通道变化.
主要方法:
- 对115名精神分裂症患者 (48名抗药性AVH,67名可治疗的AVH) 和70名健康对照 (HC) 的回顾性分析.
- 白质 (WM) 完整性在基线和5年后使用基于通道的空间统计 (TBSS) 和分数异构 (FA) 进行测量.
- 在大脑体 (CC),皮质脊髓管和上纵囊中对FA值进行比较.
主要成果:
- 与HC患者相比,耐药AVH患者在体 (CC) 中的基线FA和皮质脊髓管中治疗后的FA较高.
- 5年后,药物耐药的AVH患者表现出较高的FA在上纵向囊中,而可治疗的AVH患者在视觉辐射和CC中显示出较高的FA.
- 两组AVH在CC的基线FA比HC更高;高级纵向囊异常与耐药AVH不同.
结论:
- 精神分裂症患者患有可治疗和耐药的AVHs共享常见的白质 (WM) 通道异常,特别是在体 (CC).
- 明显的WM异常,例如在上纵长,与药物耐药的AVH相关.
- 这些WM通道的差异可能是发生AVH的精神分裂症患者对抗精神病药物的不同治疗反应的基础.
相关概念视频
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Schizophrenia
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...


