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在精神分裂症患者有听觉幻觉的替代性听觉注意力期间,听觉效应抑制
Che Muhammad Amir Che Awang1, Noor Alaudin Abdul Wahab1,2,3, Siti Aisyah Mohammad Tahir1
1Audiology Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia.
Scientific reports
|March 21, 2025
概括
最近有口头听觉幻觉的精神分裂症患者表现出改变的不同听觉通路功能. ALAUDIN©-CSOAE测试可能有助于区分这些患者与健康个体.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 精神病学是一个精神病学.
背景情况:
- 听觉幻觉在精神分裂症并没有完全理解.
- 涉及到不同听觉系统中的异常.
- 听力皮层和耳之间的自上而下的连接是关键.
研究的目的:
- 调查精神分裂症患者与口头听觉幻觉 (VAHs) 的听觉系统.
- 评估将替代听觉注意力 (ALAUDIN©) 任务与对侧抑制耳声排放 (CSOAE) 的实用性.
主要方法:
- 使用ALAUDIN©任务与CSOAE结合测量耳外毛细胞抑制.
- 评估了57名健康对照组 (HCs) 和10名精神分裂症患者 (5名近期幻觉 - SRH,5名非近期幻觉 - SNRH).
- 应用的反侧抑制剂,包括单独的白噪声 (WN) 和ALAUDIN©任务.
主要成果:
- 在不同组的抑制中没有明显的耳朵差异.
- 在SRH群体中,对逆侧抑制剂4 (CS4) 的抑制显著大于HCs.
- ALAUDIN©任务有效地测量了不同的听觉通路异常.
结论:
- 通过ALAUDIN©-CSOAE测试,可以测量精神分裂症中不同听觉通路的功能.
- 这种测试可以区分精神分裂症患者最近的VAH与健康个体.
- 需要更大的样本大小来验证.
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