慢性病患者的De-Ritis比率 (AST/ALT) 和死亡率之间的关联:一个回顾性队列研究
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1Department of Nephrology, Guangzhou Twelfth People's Hospital, Guangzhou, 510630, Guangdong, China.
Scientific reports
|March 21, 2025
概括
德-利茨比率 (AST/ALT比率) 与慢性病 (CKD) 患者的高死亡率有关. 较高的比率表明,CKD患者的全因死亡率和心血管疾病死亡率的风险增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床生物化学 临床生物化学
- 流行病学 流行病学
背景情况:
- 德-利特斯比率 (AST/ALT比率) 是严重病患者死亡率的既定预测指标.
- 关于其在慢性病 (CKD) 患者的预后价值的数据有限.
研究的目的:
- 为了研究De-Ritis比率和死亡率之间的联系,在一组患有CKD的美国成年人中.
- 确定De-Ritis比率是否可以作为CKD人口中死亡率的预测生物标志物.
主要方法:
- 一项回顾性队列研究,利用了国家健康和营养检查调查 (2007-2016) 中2728名参与者的数据.
- 参与者按De-Ritis比率三级分层.
- 采用多变量Cox比例危险回归模型来分析与所有原因和心血管疾病 (CVD) 死亡率的关联.
主要成果:
- 全因死亡率的总发病率为24.2%,心血管疾病死亡率为5.8%.
- 较高的De-Ritis比率水平显著与所有原因和心血管疾病死亡率的风险增加有关.
- 在多变量调整后,De-Ritis比率≥1.32的个体与比率≤0.98的个体相比,具有显著更高的全因死亡率 (HR 1.50) 和心血管疾病死亡率 (HR 2.02) 的风险.
结论:
- 较高的De-Ritis比率与CKD人口中所有原因和心血管疾病死亡率的增加显著相关.
- De-Ritis比率可以作为慢性病患者死亡风险的简单,成本有效的预后指标.
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