大脑手性关联取决于手性如何以及何时被测量
Link Tejavibulya1, Corey Horien2,3, Carolyn Fredricks4
1Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA. link.tejavibulya@yale.edu.
Scientific reports
|March 21, 2025
概括
脑 - 手性关联因年龄组和测量方法而异. 这项研究强调了手偏好如何与大脑结构相关的代际差异,并警告在神经成像研究中不要采用简单的方法.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑成像技术
- 认知科学 认知科学
背景情况:
- 手的偏好通常简化为右撇子或左撇子,这些群体之间确立的大脑差异.
- 对手性的二元化观点忽视了跨活动和世代的大脑手性关联的变化.
- 几代人之间改变的手动使用模式 (例如,写作与发短信) 可能会影响大脑与手的关系.
研究的目的:
- 通过大规模的神经成像数据集,研究大脑手性关联的代际差异.
- 为了检查不同衡量手性对观察到的大脑手性关联的影响.
- 探索与年龄相关的环境影响在手偏好和大脑功能连接组之间的关系.
主要方法:
- 利用了来自两个大型数据集的静止状态功能连接体:人类连接体项目-开发 (HCP-D) 和人类连接体项目-衰老 (HCP-A).
- 通过使用爱丁堡手性库存中的九个项目来评估手性.
- 在不同年龄段 (童年/青春期与成年/老年期) 进行了对比的大脑与手术的关联.
主要成果:
- 在HCP-D和HCP-A队列之间的脑手性关联中观察到显著的差异.
- 大脑与手的关联中的这些代际差异取决于用于测量手性的特定方法.
- 该研究确定了功能性大脑连接体如何与不同年龄组和测量技术的手偏好相关的变异性.
结论:
- 脑 - 手性关联不均,并表现出跨世代和测量方法的显著变化.
- 对手性有细微的理解至关重要,超越简单的右/左二分法.
- 关于手性的神经成像研究应该考虑代际背景的影响和选择的手性评估方法,以避免过度简化.
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