循环节相位逆转在夜间工作和时差差的老鼠模型中引起胰岛素抵抗
Anhui Wang1,2,3,4, Ewout Foppen3,4, Valentina S Rumanova1,2,3,4,5
1Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Scientific reports
|March 21, 2025
概括
轮班工作破坏昼夜节律,增加2型糖尿病的风险. 剧烈的光/黑暗周期变化会导致胰岛素耐药性,但黑暗时期的食有助于大鼠的适应.
科学领域:
- 时间生物学 时间生物学
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
背景情况:
- 轮班工作与患2型糖尿病的风险增加有关.
- 摄入食物的时间是代谢调节和昼夜节律的关键因素.
研究的目的:
- 研究轮班工人胰岛素耐药性背后的机制.
- 检查食物摄入时间在适应昼夜干扰中的作用.
主要方法:
- 雄性Wistar大鼠接受了光/黑暗周期的急性12小时相位逆转.
- 在阶段转换之前和之后进行了静脉输血葡萄糖耐受性测试 (GTT).
- 代谢监测了不同养条件下的活性,能量消耗和皮质水平 (随心所欲,仅限于光明或黑暗时期).
主要成果:
- 葡萄糖耐受性和皮质的循环节律在阶段转移后的三天内适应.
- 阶段逆转在活性阶段开始时诱导了胰岛素抵抗.
- 在ad libitum养下,机动活动和能量消耗节奏比其他行为更快地适应.
- 将食物摄入量限制在黑暗时期,增强了对逆光/黑暗周期的行为适应.
结论:
- 通过光/黑暗循环逆转而引起的急性昼夜干扰导致胰岛素抵抗.
- 食物摄入时间显著影响行为和代谢适应昼夜不整.
- 像定时养这样的策略可以减轻与轮班工作相关的代谢风险.
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