路易斯安那州不良妊娠结果的趋势,2017年至2022年
Chelsea L Kracht1, Emily W Harville2, Nicole L Cohen2
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Scientific reports
|March 21, 2025
概括
随着COVID-19的流行,妊娠期糖尿病和子宫前症等不良妊娠结果显著增加,特别是在怀孕早期. 在压力事件期间支持孕妇对于预防严重的孕产妇发病率至关重要.
科学领域:
- 围产期健康 围产期健康
- 流行病学 流行病学
- 孕产妇的发病率 孕产妇的发病率
背景情况:
- 众所周知,自然灾害会导致不良妊娠结果 (APO).
- 延长的COVID-19大流行对APOs和高风险围产期人口中先前存在的疾病的影响仍然不清楚.
- 在这些人群中,严重的孕产妇发病率和死亡率是严重的担忧.
研究的目的:
- 调查COVID-19流行病与不良怀孕结果之间的关联.
- 检查流行病时间对先前存在的条件和APO的影响.
- 在大流行期间确定围产期人口中严重孕产妇发病率和死亡率的风险.
主要方法:
- 在路易斯安那州的一个大型分娩医院,从2017年到2022年对医院记录和出生证明进行了回顾性图表审查.
- 分析包括27,877名分娩,比较大流行前,大流行早期,大流行高峰期和大流行后期的受孕和分娩期.
- 统计分析包括调整的相对风险 (aRR) 和调整的几率比率 (aOR) 与95%置信区间 (CI).
主要成果:
- 孕期糖尿病 (GDM) 的发病率从大流行前的11.0%增加到大流行初期的16.4% (aRR: 1.47,95%CI 33,63).
- 孕前和HELLP综合征在早期,高峰期和晚期的流行病分娩中更有可能发生 (aRR:1.54-1.62).
- 慢性高血压的风险增加了17% (95% CI 5,32) 在峰值流行概念期间.
结论:
- COVID-19 流行病与孕妇糖尿病,孕前,HELLP 综合征和孕妇慢性高血压的风险增加有关.
- 与大流行前的怀孕相比,早期的流行概念显示妊娠糖尿病的风险明显更高 (aOR:3.26,95% CI 1.52,6.97).
- 在压力事件期间,特别是怀孕早期,为分娩人员提供支持,对于预防不良妊娠结果和严重的孕产妇发病率至关重要.
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