休息状态连接模式与青春期特征焦虑相关
Teresa Baggio1, Alessandro Grecucci2,3, Fabrice Crivello4
1Clinical and Affective Neuroscience Lab, CL.I.A.N. Lab, Department of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Trento, Italy. teresa.baggio@unitn.it.
Scientific reports
|March 21, 2025
概括
具有较高特征焦虑的青少年在关键网络中显示大脑连接性降低,影响自我参考思维和情绪调节. 这一发现可能有助于识别青年焦虑的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 焦虑症状在青春期和成年早期普遍存在,增加了未来焦虑障碍的风险.
- 神经科学对焦虑的研究主要集中在使用单变量方法的成年人身上,经常忽视大规模的大脑变化.
- 患有特征性焦虑的青少年可能表现出与成年人相似的脑部异常,特别是在与自我参考思维和反有关的默认模式网络区域.
研究的目的:
- 在大量青少年样本中调查与特征焦虑相关的静止状态功能连接模式.
- 为了确定特定的大脑网络和区域涉及在青春期的特征焦虑.
主要方法:
- 分析了来自1263名青少年 (平均年龄为20.55岁) 的休息状态功能磁共振成像 (rs-fMRI) 数据.
- rs-fMRI连接模式与特征焦虑度的个体得分的相关性.
主要成果:
- 在两个不同的网络中,在特征焦虑和静止状态功能连接之间发现了显著的关联.
- 关键区域,包括带状回形,中回形和前 (与默认模式网络重叠),显示出改变的连接性.
- 较高的特征焦虑与这些网络内的功能连接性较低相关.
结论:
- 特定大脑网络的连接性减少与青少年更高的特征焦虑有关.
- 这些发现表明,在高焦虑的青少年中,自我参考处理,意识和情绪调节的潜在障碍.
- 这项研究可能有助于开发潜在的神经影像生物标志物,用于青少年群体的焦虑.
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