与儿童肥胖相关的FTO和NOS3基因:Corações de Ouro Preto的研究
Aline Priscila Batista1,2, Thomás Viana de Souza3,4, Luiz Antônio Alves de Menezes-Júnior4,5
1Biological Sciences Research Center, Postgraduate Program in Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. alinepriop@gmail.com.
BMC pediatrics
|March 21, 2025
概括
像FTO和NOS3基因变异这样的遗传因素与巴西的儿童肥胖有关. 这些遗传倾向,结合临床风险因素,显著增加儿童和青少年的肥胖风险.
科学领域:
- 遗传学和公共卫生
- 儿童肥胖研究儿童肥胖研究
背景情况:
- 肥胖是一种影响儿童的全球流行病,遗传因素 (SNP) 发挥着作用.
- 涉及的关键基因包括α-甲酸依赖的二氧化酶 (FTO),内皮氧化 (NOS3) 和阿波利波蛋白B (APOB).
- 遗传倾向和临床风险因素之间的相互作用需要进一步研究,特别是在巴西人群中.
研究的目的:
- 评估FTO,NOS3和APOB基因中的特定SNP与巴西儿童和青少年肥胖之间的关联.
- 研究显著SNP和临床风险因素对肥胖发展的联合影响.
主要方法:
- 一项以人口为基础的横截面研究与巴西Ouro Preto,Minas Gerais的6-17岁的孩子进行.
- 评估了社会人口统计学,临床和生化变量,与SNP rs1121980 (FTO),rs1799983 (NOS3) 和rs693 (APOB) 一起进行评估.
主要成果:
- 在研究人口中,肥胖患病率为8.5%.
- 在FTO (rs1121980 AA) 和NOS3 (rs1799983 TT) 中风险等位基因的同性显著增加了肥胖的可能性 (分别为OR2.07和2.49).
- 综合遗传风险等位基因和临床因素 (例如,非排他性母乳养,高出生体重,家族病史) 扩大了肥胖风险.
结论:
- 该研究支持FTO (rs1121980) 和NOS3 (rs1799983) SNPs在巴西城市儿童和青少年肥胖中的作用.
- 遗传倾向与环境因素相互作用,影响肥胖的发展.
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