在MASLD患者中,FIB-4指数和下肢动脉疾病之间的关联:一个横截面研究
Chunxia Zhang1, Yuchen Ying1, Yuanhui Ru2
1Department of Cardiology, Ningbo Medical Center LiHuiLi Hospital (The Affiliated LiHuiLi Hospital of Ningbo University), Ningbo, Zhejiang, China.
Lipids in health and disease
|March 21, 2025
概括
较高的纤维化-4 (FIB-4) 指数水平与患有代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的下肢动脉疾病 (LEAD) 风险增加有关. 这表明FIB-4可能有助于预测该人口中的LEAD.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 血管医学 血管医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了心血管疾病的风险,包括下肢动脉疾病 (LEAD).
- 纤维化-4 (FIB-4) 指数是肝纤维化的一种非侵入性标记,可以预测MASLD患者的LEAD.
- 这项研究调查了MASLD队列中FIB-4和LEAD之间的关联.
研究的目的:
- 探索FIB-4指数与LEAD的流行之间的关联.
- 确定FIB-4是否可以作为MASLD患者LEAD的预测标记.
主要方法:
- 来自健康检查数据库的481名MASLD患者的横截面研究.
- 参与者按FIB-4指数 (<1.3,1.3-2.66,>2.66) 分层,并接受了双重超声扫描以诊断LEAD.
- 使用了经过调整以人口统计,代谢和脂质因素的后勤回归模型;进行了子组分析.
主要成果:
- 与FIB-4水平相比,LEAD患病率上升 (51.3%在低组,至86.5%在高组,p<0.001).
- 较高的FIB-4水平与LEAD独立相关 (调整后OR:3.54).
- 每个FIB-4的单位增加与LEAD的66%更高的可能性相关 (调整后OR:1.66,P<0.001).
结论:
- 升高的FIB-4水平与MASLD患者的LEAD患病率独立相关.
- FIB-4指数显示了在这个人群中作为LEAD预测指标的潜力.
- 建议进行更大规模的研究以进一步阐明这些关联.
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