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ZEB1和ZEB2在瘤进展中的双重作用

Sergey E Parfenyev¹, Alexandra A Daks¹, Oleg Y Shuvalov¹

¹Laboratory of Gene Expression Regulation, Institute of Cytology RAS, Saint-Petersburg, 164064, Russia.

|March 21, 2025

概括

ZEB1和ZEB2蛋白质是癌症转移的关键调节者. 它们在患者生存中的作用是复杂的,可能取决于它们在健康组织中的表达水平以及它们对瘤微环境的影响.

科学领域:

分子生物学分子生物学
癌症研究癌症研究
细胞生物学细胞生物学

背景情况:

ZEB1和ZEB2是表皮层-介质细胞过渡 (EMT) 的既定调节者,这是癌症转移的关键过程.
通常情况下,高ZEB1/ZEB2表达与由于促进二次瘤形成而导致患者存活率低下相关.
然而,矛盾的观察结果将ZEB1/ZEB2与某些癌症类型的更好的预后联系起来.

研究的目的:

探索ZEB1/ZEB2对瘤发生的影响与它们在健康组织中的基线表达有所不同的假设.
审查ZEB1/ZEB2在调节瘤微环境和免疫反应中的双重作用.

主要方法:

本综述综合了现有文献和新出现的证据.
对研究ZEB1/ZEB2表达在各种健康组织和癌症环境中的研究进行分析.
讨论它们作为免疫调节器的功能.

主要成果:

ZEB1和ZEB2在几个健康组织中构成性表达,执行重要的生理功能.
这些组织中ZEB1/ZEB2的减少表达可能会导致疾病的发展,包括癌症.
ZEB1/ZEB2在免疫调节中表现出双重作用,影响瘤微环境.

结论:

ZEB1/ZEB2的瘤性作用取决于上下文,受其在正常组织中的表达状态的影响.
了解这种二元性对于开发有针对性的癌症疗法至关重要.
ZEB1/ZEB2对瘤微环境的影响需要进一步研究.

关键词:

癌症癌症癌症癌症致癌的发生是致癌的产生.皮质 - 介质细胞过渡.在ZEB1和ZEB2之间.

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