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Updated: Aug 4, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
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An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

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光诱导的gRNA表达允许在体内对T淋巴细胞进行光遗传基因编辑

Diego Velasquez Pulgarin1,2, Nathalie Pelo1, Lin Ferrandiz1

  • 1Center for Molecular Medicine, Department of Medicine (K2), Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.

Nucleic acids research
|March 21, 2025
PubMed
概括

研究人员开发了一种新的光遗传CRISPR工具BLU-VIPR,用于精确的基因编辑. 这个系统使用蓝光控制基因扰动,使得CRISPRa和基础编辑等应用 in vivo.

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Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

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Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System05:28

Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System

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相关概念视频

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...