活性诱导:增强乳酸细菌生物活性的一个有希望的策略
Sisi Chen1,2, Keke Suo1,2, Qiaozhen Kang1,2
1School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Critical reviews in food science and nutrition
|March 21, 2025
概括
活性诱导通过改善应激反应来增强乳酸细菌 (LAB) 的功能和益生菌的益处. 这一战略促进了LAB的发展.
科学领域:
- 微生物学 微生物学
- 益生菌 益生菌 益生菌
- 食品科学 食品科学 食品科学
背景情况:
- 乳酸细菌 (LAB) 是对人类健康至关重要的益生菌.
- LAB的生存和功能取决于它们适应环境压力的能力.
- 积极诱导是一种有前途的策略,可以调节LAB的生物活动并增强健康益处.
研究的目的:
- 审查各种主动诱导方法对LAB功能活动的有益影响.
- 通过使用先进的奥米克和计算方法,探索LAB中的压力调节网络.
- 突出积极诱导在加强LAB在食品应用中的作用方面的潜力.
主要方法:
- 关于活性诱导策略 (酸,胆,氧化,乙醇,热,冷,辐射) 的文献综述.
- 利用omics方法,in silico分析和基因编辑来探索压力调节网络.
- 在LAB中调查活性成分和应力适应器的识别.
主要成果:
- 活性诱导增强了LAB应激耐受性,交叉保护,肠道殖民化和粘附.
- 通过活性诱导,LAB可以提供抗酒精和肝脏保护.
- 与压力相关的基因和蛋白质受到调节,生物活性代谢物通过活性诱导被诱导.
结论:
- 积极诱导策略显著提高LAB的功能活动和健康益处.
- 先进的技术有助于更深入地了解LAB应激反应机制.
- 积极诱导具有很大的潜力,可以改善食品行业的LAB应用.
相关概念视频
00:46Feedback Inhibition
53.5K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
53.5K
01:33Bacterial Transformation
55.0K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.0K